APOE-ε4 and APOE −491A polymorphisms in individuals with subjective memory loss
نویسندگان
چکیده
منابع مشابه
Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife
Short-term memory in middle-aged individuals with different APOE alleles was examined using a recently developed task which is sensitive to medial temporal lobe (MTL) damage. Individuals (age-range: 40-51 years) with ε3/ε3, ε3/ε4 and ε4/ε4 APOE genotypes (N = 60) performed a delayed estimation task with a sensitive continuous measure of report. The paradigm allowed us to measure memory for item...
متن کاملAPOE ε4 genotype predicts memory for everyday activities.
The apolipoprotein E (ApOE) ε4 allele is associated with neuropathological buildup of amyloid in the brain, and with lower performance on some laboratory measures of memory in some populations. In two studies, we tested whether ApOE genotype affects memory for everyday activities. In Study 1, participants aged 20-79 years old (n = 188) watched movies of actors engaged in daily activities and co...
متن کاملAPOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature.
The APOE-ε4 allele correlates with increased risk of Alzheimer disease (AD) and increased parenchymal amyloid plaques. We tested how the APOE genotype correlated with cerebral amyloid angiopathy (CAA) by analyzing 371 brains for parenchymal and meningeal CAA in 4 brain regions (frontal, parietal, temporal, and occipital neocortex). The overall severity of CAA was highest in the occipital lobe. ...
متن کاملAssociation between APOE ε4 Genotype and Memory Impairment in Elderly with Normal Global Cognitive Assessment
AIM Early prediction using cognitive evaluation tools that are less influenced by education level is beneficial for dementia screening. This study investigated the relationship between Word List Memory Immediate Recall (WLM IR) and the Saving Score (SS) with having the APOE ε4 risk allele in the elderly with normal global cognitive assessment. METHODS A cross-sectional study on 105 subjects ≥...
متن کاملBlood pressure interacts with APOE ε4 to predict memory performance in a midlife sample.
OBJECTIVE Elevated blood pressure and the Apolipoprotein ε4 allele (APOE ε4) are independent risk factors for Alzheimer's disease. We sought to determine whether the combined presence of the APOE ε4 allele and elevated blood pressure is associated with lower cognitive performance in cognitively healthy middle-aged adults. METHODS A total of 975 participants aged 30-54 (mean age = 44.47) were ...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2002
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001083